megatomi.com - An Overview
megatomi.com - An Overview
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Our new Clear+ tissue clearing approach is the sole strategy that delipidates samples without having change in morphology and with minimal impact on structural integrity.
Megatome can be a vibrating microtome built to portion a wide range of samples, from organoids and biopsy samples to expanded rodent brains and intact human organs. With higher blade vibrating frequency and minimized blade deflection, Megatome enables large-throughput tissue sectioning with uniform floor profile, together with negligible tissue destruction and knowledge loss.
Antibodies might take weeks to diffuse as a result of only a few millimeters of tissue, having a steep labeling gradient from surface area to Main.
Megatome is created for accuracy: the blade vibrates at a better frequency and larger amplitude assortment than other microtomes, and includes a special deflection Handle mechanism.
SE utilizes a rotational electric field to disperse highly electromobile molecules (like antibodies or surfactant micelles) all through a porous sample with out damaging electrically billed buildings in the tissue. This enables 2-4 working day clearing of intact organs,
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Megatome is actually a novel microtome which allows for prime-precision sectioning of a wide megatomi.com range of tissue samples – from organoids, to arrays of animal organs, to intact human Mind hemispheres – with small tissue damage and information decline.
It’s the perfect time to up grade your microtome to Megatome. With exact significant-frequency slicing for an unmatched range of sample measurements and types – from organoids and tumors to expanded tissues, sample arrays, and intact primate organs – Megatome is optimized for numerous purposes.
The SmartSPIM gentle sheet microscope gives unparalleled resolution and acquisition speed in the course of intact tissue volumes, though its modular design and style permits you to enhance and personalize person factors.
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SHIELD avoids the variability of hydrogel embedding and the information reduction from PFA preservation, shielding specimens for multiple rounds of processing.
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Our novel SHIELD tissue preservation approach kinds intramolecular bonds employing polyfunctional, versatile epoxides to stabilize tissue architecture and safeguard the sample’s endogenous fluorescence, protein antigenicity and nucleic acids.